Misfolded Proteins

Google Image Result for http://www.bu.edu/dbin/anatneuro/assets/images/pics/lab/fmri.jpg: "Accumulation of misfolded proteins is a feature of aging and appears to be accelerated in many neurodegenerative disorders. Protein misfolding can result from defects in the chaperone system or may arise due to mutations or oxidative damage. Recent data indicates that the misfolded proteins play an active role in cellular toxicity. "